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New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
Zhu, Weixing Haupenthal, Jörg Groh, Matthias Fountain, Michelle Hartmann, Rolf W
Zhu, Weixing
Haupenthal, Jörg
Groh, Matthias
Fountain, Michelle
Hartmann, Rolf W
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2014-07
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CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.
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New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother.
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en
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1098-6596
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Archived with thanks to Antimicrobial agents and chemotherapy