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OPTIMIZATION OF FERMENTATION PLANTS
Blachère, Henri T. Peringer, Paul Corrieu, Georges V.
Blachère, Henri T.
Peringer, Paul
Corrieu, Georges V.
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1976
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2022-11-02
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Abstract
Techniques for estimation of investment and manufacturing costs in fermentation
are discussed.
A method for optimization of fermentation Plants as whole is described. 5
It necessitates knowledge of a model of the biosynthesis and equations correlating
investment and manufacturing costs to the size of equipment.
The Minimization of the non-linear objective function in a non-convex field
is obtained by a two step method.
Optimization in fermentation industry may have numerous aspects. One may envision
improving the growth rate, the production rate or the yield in compound biosynthesis.
In this case, the main control parameters are : substrate concentrations,
temperature, pH, aeration and agitation etc... Since a mathematical model of microbial
cell-growth has been formulated by Monod (1), the kinetic pattern of various
fermentation systems has been intensively studied. The number of publications in
this field is strongly increasing (2,3,4,5,6).
The problem concerning the reduction of manufacturing costs such as those of
steam, energy of agitation and aeration, consumption of air, water and raw materials
belong to another category of optimization. Okabe and Aiba have recently presented
solutions to these problems (7,8,9,10,11).
The purpose of this paper concerns the approach of a global optimization of a
new plan supposing that the annual production of a fermentation product is given,
then the optimization consists in determining the size of the fermentor, power of
agitation and aeration system, size of heat exchangers, pumps, filters, centrifuges
etc... the required condition for temperature, pH, dissolved oxygen, substrate concentration
etc... so that the investment capital and annual expenditure for the production
be minimized.
Since the same control variables and equipment are used in most fermentation industries,
we consider that the method proposed, as regards yeast production, will also
apply to various other production.
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Workshop Computer Apllications in Fermentation Technology 1976, 1 - 10
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en
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Attribution-ShareAlike 4.0 International