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CMV and Immunosenescence: from basics to clinics.
Solana, Rafael Tarazona, Raquel Aiello, Allison E Akbar, Arne N Appay, Victor Beswick, Mark Bosch, Jos A Campos, Carmen Cantisán, Sara Cicin-Sain, Luka
Solana, Rafael
Tarazona, Raquel
Aiello, Allison E
Akbar, Arne N
Appay, Victor
Beswick, Mark
Bosch, Jos A
Campos, Carmen
Cantisán, Sara
Cicin-Sain, Luka
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Abstract
Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
Citation
CMV and Immunosenescence: from basics to clinics. 2012, 9 (1):23 Immun Ageing
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Journal
PubMed ID
PubMed Central ID
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Article
Language
en
Description
Series/Report no.
ISSN
1742-4933