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Optimizing Salmonella enterica serovar Typhimurium for bacteria-mediated tumor therapy.
Felgner, Sebastian Kocijancic, Dino Frahm, Michael Curtiss, Roy Erhardt, Marc Weiss, Siegfried
Felgner, Sebastian
Kocijancic, Dino
Frahm, Michael
Curtiss, Roy
Erhardt, Marc
Weiss, Siegfried
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Abstract
Bacteria-mediated tumor therapy using Salmonella enterica serovar Typhimurium is a therapeutic option with great potential. Numerous studies explored the potential of Salmonella Typhimurium for therapeutic applications, however reconciling safety with vectorial efficacy remains a major issue. Recently we have described a conditionally attenuated Salmonella vector that is based on genetic lipopolysaccharide modification. This vector combines strong attenuation with appropriate anti-tumor properties by targeting various cancerous tissues in vivo. Therefore, it was promoted as an anti-tumor agent. In this addendum, we summarize these findings and demonstrate additional optimization steps that may further improve the therapeutic efficacy of our vector strain.
Citation
Optimizing Salmonella enterica serovar Typhimurium for bacteria-mediated tumor therapy. 2016, 7 (2):171-7 Gut Microbes
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Journal
PubMed ID
PubMed Central ID
PMC4856459
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Article
Language
en
Description
Series/Report no.
ISSN
1949-0984