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Synthesis of the spiroketal core of integramycin.

Prusov, Evgeny V
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2013
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Abstract
A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.
Citation
Synthesis of the spiroketal core of integramycin. 2013, 9:2446-50 Beilstein J Org Chem
Affiliation
Department of Medicinal Chemistry, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany
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Beilstein journal of organic chemistry
URI
http://hdl.handle.net/10033/310994
DOI
10.3762/bjoc.9.282
PubMed ID
24367411
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Article
Language
en
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1860-5397
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Archived with thanks to Beilstein journal of organic chemistry
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publications of the department medicinal chemistry (MCH)