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Peptide-mediated interference with influenza A virus polymerase.
Ghanem, Alexander Mayer, Daniel Chase, Geoffrey Tegge, Werner Frank, Ronald Kochs, Georg García-Sastre, Adolfo Schwemmle, Martin
Ghanem, Alexander
Mayer, Daniel
Chase, Geoffrey
Tegge, Werner
Frank, Ronald
Kochs, Georg
García-Sastre, Adolfo
Schwemmle, Martin
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2007-07
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Abstract
The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.
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Peptide-mediated interference with influenza A virus polymerase. 2007, 81 (14):7801-4 J. Virol.
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en
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0022-538X